OCLN Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant OCLN.
|Application ||WB, IF, IP, E|
|Calculated MW||59144 Da|
|Other Names||Occludin, OCLN|
|Target/Specificity||OCLN (NP_002529, 423 a.a. ~ 522 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||OCLN Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described.
Nedd4-2 interacts with occludin to inhibit tight junction formation and enhance paracellular conductance in collecting duct epithelia. Raikwar NS, et al. Am J Physiol Renal Physiol, 2010 Aug. PMID 20504882.Splicing diversity of the human OCLN gene and its biological significance for hepatitis C virus entry. Kohaar I, et al. J Virol, 2010 Jul. PMID 20463075.Tight junction-associated MARVEL proteins marveld3, tricellulin, and occludin have distinct but overlapping functions. Raleigh DR, et al. Mol Biol Cell, 2010 Apr 1. PMID 20164257.The tight junction protein, occludin, regulates the directional migration of epithelial cells. Du D, et al. Dev Cell, 2010 Jan 19. PMID 20152177.Identification of MarvelD3 as a tight junction-associated transmembrane protein of the occludin family. Steed E, et al. BMC Cell Biol, 2009 Dec 22. PMID 20028514.
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