PHGDH Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant PHGDH.
|Application ||WB, IHC, IF, IP|
|Calculated MW||56651 Da|
|Other Names||D-3-phosphoglycerate dehydrogenase, 3-PGDH, PHGDH, PGDH3|
|Target/Specificity||PHGDH (AAH11262.1, 1 a.a. ~ 533 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PHGDH Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
3-Phosphoglycerate dehydrogenase (PHGDH; EC 220.127.116.11) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.
1.Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis.Pollari S, Kakonen SM, Edgren H, Wolf M, Kohonen P, Sara H, Guise T, Nees M, Kallioniemi O.Breast Cancer Res Treat. 2010 Mar 30. [Epub ahead of print]
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