PIR Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a full length recombinant PIR.
|Calculated MW||32113 Da|
|Other Names||Pirin, Probable quercetin 2, 3-dioxygenase PIR, Probable quercetinase, PIR|
|Target/Specificity||PIR (AAH02517, 1 a.a. ~ 290 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PIR Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.
Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches. Licciulli S, et al. BMC Cell Biol, 2010 Jan 20. PMID 20089166.Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation. Licciulli S, et al. Leukemia, 2010 Feb. PMID 20010624.Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese. Tang NL, et al. Bone, 2010 Feb. PMID 19766747.Structural and biochemical analysis reveal pirins to possess quercetinase activity. Adams M, et al. J Biol Chem, 2005 Aug 5. PMID 15951572.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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