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POLS Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant POLS.
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Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.73 KDa) .
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Western blot analysis of POLS over-expressed 293 cell line, cotransfected with POLS Validated Chimera RNAi ( (Cat # AT3380a )
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Detection limit for recombinant GST tagged POLS is approximately 0.3ng/ml as a capture antibody.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q5XG87 |
| Other Accession | NM_006999 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 2F8 |
| Calculated MW | 84650 Da |
| Gene ID | 11044 |
|---|---|
| Other Names | Non-canonical poly(A) RNA polymerase PAPD7, DNA polymerase sigma, LAK-1, PAP-associated domain-containing protein 7, TRAMP-like complex polyadenylate polymerase, Terminal uridylyltransferase 5, TUTase 5, Topoisomerase-related function protein 4-1, TRF4-1, PAPD7, POLS, TRF4 |
| Target/Specificity | POLS (NP_008930, 2 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | POLS Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a DNA polymerase that is likely involved in DNA repair. In addition, the encoded protein may be required for sister chromatid adhesion. Alternatively spliced transcript variants that encode different isoforms have been described.
References
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. Need AC, et al. Hum Mol Genet, 2009 Dec 1. PMID 19734545.Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061.Genome-wide association study of response to methylphenidate in 187 children with attention-deficit/hyperactivity disorder. Mick E, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Dec 5. PMID 18821564.A genome-wide scan maps a novel high myopia locus to 5p15. Lam CY, et al. Invest Ophthalmol Vis Sci, 2008 Sep. PMID 18421076.Discovery of genetic profiles impacting response to chemotherapy: application to gemcitabine. Jarjanazi H, et al. Hum Mutat, 2008 Apr. PMID 18330920.
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