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POU4F3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant POU4F3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q15319 |
| Other Accession | NM_002700 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5B8 |
| Calculated MW | 37052 Da |
| Gene ID | 5459 |
|---|---|
| Other Names | POU domain, class 4, transcription factor 3, Brain-specific homeobox/POU domain protein 3C, Brain-3C, Brn-3C, POU4F3, BRN3C |
| Target/Specificity | POU4F3 (NP_002691, 100 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | POU4F3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.
References
A novel frameshift mutation of POU4F3 gene associated with autosomal dominant non-syndromic hearing loss. Lee HK, et al. Biochem Biophys Res Commun, 2010 Jun 4. PMID 20434433.Molecular modelling insights into DFNA15 mediated enhancement of POU4F3 stability. Frenz CM, et al. Int J Comput Biol Drug Des, 2008. PMID 20054994.Mild and variable audiometric and vestibular features in a third DFNA15 family with a novel mutation in POU4F3. de Heer AM, et al. Ann Otol Rhinol Laryngol, 2009 Apr. PMID 19462854.Vestibular impairment in a Dutch DFNA15 family with an L289F mutation in POU4F3. van Drunen FJ, et al. Audiol Neurootol, 2009. PMID 19372648.Audiometric characteristics of a Dutch family linked to DFNA15 with a novel mutation (p.L289F) in POU4F3. Pauw RJ, et al. Arch Otolaryngol Head Neck Surg, 2008 Mar. PMID 18347256.
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