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PPM1B Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant PPM1B.
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, IP, E |
|---|---|
| Primary Accession | O75688 |
| Other Accession | BC012002 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1A3-2A4 |
| Calculated MW | 52643 Da |
| Gene ID | 5495 |
|---|---|
| Other Names | Protein phosphatase 1B, Protein phosphatase 2C isoform beta, PP2C-beta, PPM1B, PP2CB |
| Target/Specificity | PPM1B (AAH12002, 1 a.a. ~ 192 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PPM1B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Sun W, et al. Cell Signal, 2009 Jan. PMID 18930133.Phosphatase PPM1A regulates phosphorylation of Thr-186 in the Cdk9 T-loop. Wang Y, et al. J Biol Chem, 2008 Nov 28. PMID 18829461.Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Xiao K, et al. Proc Natl Acad Sci U S A, 2007 Jul 17. PMID 17620599.Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
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