PPOX Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PPOX.
|Application ||WB, IHC, E|
|Calculated MW||50765 Da|
|Other Names||Protoporphyrinogen oxidase, PPO, PPOX|
|Target/Specificity||PPOX (AAH02357, 378 a.a. ~ 477 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||PPOX Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.
1.Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase.Yang DF, Lee JW, Chen HM, Huang Z, Hsu YCJ Formos Med Assoc. 2014 Jan 29. pii: S0929-6646(13)00452-X. doi: 10.1016/j.jfma.2013.12.005.2.Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.Crooks DR, Ghosh MC, Haller RG, Tong WH, Rouault TA.Blood. 2010 Jan 28;115(4):860-9. Epub 2009 Nov 25.
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