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PPOX Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PPOX.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P50336 |
| Other Accession | BC002357 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2F10 |
| Calculated MW | 50765 Da |
| Gene ID | 5498 |
|---|---|
| Other Names | Protoporphyrinogen oxidase, PPO, PPOX |
| Target/Specificity | PPOX (AAH02357, 378 a.a. ~ 477 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PPOX Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.
References
1.Methotrexate enhances 5-aminolevulinic acid-mediated photodynamic therapy-induced killing of human SCC4 cells by upregulation of coproporphyrinogen oxidase.Yang DF, Lee JW, Chen HM, Huang Z, Hsu YCJ Formos Med Assoc. 2014 Jan 29. pii: S0929-6646(13)00452-X. doi: 10.1016/j.jfma.2013.12.005.2.Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery.Crooks DR, Ghosh MC, Haller RG, Tong WH, Rouault TA.Blood. 2010 Jan 28;115(4):860-9. Epub 2009 Nov 25.
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