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Mouse monoclonal antibody raised against a full length recombinant PROCR.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, IF |
|---|---|
| Primary Accession | Q9UNN8 |
| Other Accession | BC014451 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | M2 |
| Calculated MW | 26671 Da |
| Gene ID | 10544 |
|---|---|
| Other Names | Endothelial protein C receptor, Activated protein C receptor, APC receptor, Endothelial cell protein C receptor, CD201, PROCR, EPCR |
| Target/Specificity | PROCR (AAH14451.1, 1 a.a. ~ 238 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PROCR Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.
References
1.Inhibitory effects of epi-sesamin on endothelial protein C receptor shedding in vitro and in vivo.Ku SK, Lee W, Yoo H, Han CK, Bae JSInflamm Res. 2013 Jul 25.2.Rosmarinic acid down-regulates endothelial protein C receptor shedding in vitro and in vivo.Ku SK, Yang EJ, Song KS, Bae JSFood Chem Toxicol. 2013 Jun 14;59C:311-315. doi: 10.1016/j.fct.2013.06.003.3.Down-regulation of endothelial protein C receptor shedding by persicarin and isorhamnetin-3-O-galactoside.Ku SK, Han MS, Bae JSThromb Res. 2013 May 30. pii: S0049-3848(13)00196-5. doi: 10.1016/j.thromres.2013.05.004.4.Emodin-6-O-?]-D-glucoside down-regulates endothelial protein C receptor shedding.Lee W, Ku SK, Bae JSArch Pharm Res. 2013 Apr 16.
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