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PRPF3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PRPF3.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O43395 |
| Other Accession | NM_004698 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 3H6 |
| Calculated MW | 77529 Da |
| Gene ID | 9129 |
|---|---|
| Other Names | U4/U6 small nuclear ribonucleoprotein Prp3, Pre-mRNA-splicing factor 3, hPrp3, U4/U6 snRNP 90 kDa protein, PRPF3, HPRP3, PRP3 |
| Target/Specificity | PRPF3 (NP_004689, 585 a.a. ~ 683 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PRPF3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. This gene product is one of several proteins that associate with U4 and U6 snRNPs. Mutations in this gene are associated with retinitis pigmentosa-18.
References
1.PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa.Tanackovic G, Ransijn A, Thibault P, Abou Elela S, Klinck R, Berson EL, Chabot B, Rivolta C.Hum Mol Genet. 2011 Mar 23. [Epub ahead of print]
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