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PRPS2 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant PRPS2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P11908 |
| Other Accession | NM_002765 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4C1 |
| Calculated MW | 34769 Da |
| Gene ID | 5634 |
|---|---|
| Other Names | Ribose-phosphate pyrophosphokinase 2, PPRibP, Phosphoribosyl pyrophosphate synthase II, PRS-II, PRPS2 |
| Target/Specificity | PRPS2 (NP_002756, 160 a.a. ~ 269 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PRPS2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a phosphoribosyl pyrophosphate synthetase that plays a central role in the synthesis of purines and pyrimidines. The encoded protein catalyzes the synthesis of 5-phosphoribosyl 1-pyrophosphate from ATP and D-ribose 5-phosphate. Alternate splicing results in multiple transcript variants.
References
Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells. Mannava S, et al. Cell Cycle, 2008 Aug. PMID 18677108.[Increased activity of PRPP synthetase] Iizasa T. Nippon Rinsho, 2008 Apr. PMID 18409517.Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
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