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PTGIR Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant PTGIR.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P43119 |
| Other Accession | NM_000960 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 4B10 |
| Calculated MW | 40956 Da |
| Gene ID | 5739 |
|---|---|
| Other Names | Prostacyclin receptor, Prostaglandin I2 receptor, PGI receptor, PGI2 receptor, Prostanoid IP receptor, PTGIR, PRIPR |
| Target/Specificity | PTGIR (NP_000951, 296 a.a. ~ 386 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | PTGIR Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and inhibition of platelet aggregation through binding to this receptor.
References
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Interaction of the human prostacyclin receptor with Rab11: characterization of a novel Rab11 binding domain within alpha-helix 8 that is regulated by palmitoylation. Reid HM, et al. J Biol Chem, 2010 Jun 11. PMID 20395296.Prostaglandin receptors EP2 and IP are detectable in atherosclerotic arteries and plaques. Muto A, et al. Int Angiol, 2010 Apr. PMID 20357748.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.Estrogen increases expression of the human prostacyclin receptor within the vasculature through an ERalpha-dependent mechanism. Turner EC, et al. J Mol Biol, 2010 Feb 26. PMID 20070947.
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