RAD54B Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant RAD54B.
|Application ||WB, IF, E|
|Calculated MW||34768 Da|
|Other Names||Fibrinogen silencer-binding protein, FSBP|
|Target/Specificity||RAD54B (AAH01965, 801 a.a. ~ 910 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||RAD54B Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This protein binds to double-stranded DNA, and displays ATPase activity in the presence of DNA. This gene is highly expressed in testis and spleen, which suggests active roles in meiotic and mitotic recombination. Homozygous mutations of this gene were observed in primary lymphoma and colon cancer.
Gamma-Radiation Sensitivity and Polymorphisms in RAD51L1 Modulate Glioma Risk. Liu Y, et al. Carcinogenesis, 2010 Jul 7. PMID 20610542.Variation within DNA repair pathway genes and risk of multiple sclerosis. Briggs FB, et al. Am J Epidemiol, 2010 Jul 15. PMID 20522537.Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk. McWilliams RR, et al. Cancer Epidemiol Biomarkers Prev, 2009 Sep. PMID 19690177.Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. Kweekel DM, et al. Br J Cancer, 2009 Jul 21. PMID 19536092.Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing. McManus KJ, et al. Proc Natl Acad Sci U S A, 2009 Mar 3. PMID 19218431.
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