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RASA1 Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant RASA1.

  • WB - RASA1 Antibody (monoclonal) (M01) AT3574a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.74 KDa) .
  • WB - RASA1 Antibody (monoclonal) (M01) AT3574a
    RASA1 monoclonal antibody (M01), clone 2C12 Western Blot analysis of RASA1 expression in IMR-32 ( (Cat # AT3574a )
  • IHC - RASA1 Antibody (monoclonal) (M01) AT3574a
    Immunoperoxidase of monoclonal antibody to RASA1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 6 ug/ml]
  • E - RASA1 Antibody (monoclonal) (M01) AT3574a
    Detection limit for recombinant GST tagged RASA1 is 0.3 ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P20936
Other Accession NM_002890
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG1 kappa
Clone Names 2C12
Calculated MW 116403 Da
Additional Information
Gene ID 5921
Other Names Ras GTPase-activating protein 1, GAP, GTPase-activating protein, RasGAP, Ras p21 protein activator, p120GAP, RASA1, GAP, RASA
Target/Specificity RASA1 (NP_002881, 948 a.a. ~ 1047 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsRASA1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.


Identification of several novel non-p.R132 IDH1 variants in thyroid carcinomas. Hemerly JP, et al. Eur J Endocrinol, 2010 Aug 11. PMID 20702649.Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia. Wiemels JL, et al. Blood Cells Mol Dis, 2010 Oct 15. PMID 20688547.MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis. Anand S, et al. Nat Med, 2010 Aug. PMID 20676106.High frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine. Bachas C, et al. Blood, 2010 Jun 30. PMID 20592250.A novel association between RASA1 mutations and spinal arteriovenous anomalies. Thiex R, et al. AJNR Am J Neuroradiol, 2010 Apr. PMID 20007727.

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$ 315.00
Cat# AT3574a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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