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SAV1 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant SAV1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H4B6 |
| Other Accession | NM_021818 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3A10 |
| Calculated MW | 44634 Da |
| Gene ID | 60485 |
|---|---|
| Other Names | Protein salvador homolog 1, 45 kDa WW domain protein, hWW45, SAV1, WW45 |
| Target/Specificity | SAV1 (NP_068590, 300 a.a. ~ 383 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SAV1 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.
References
The human WW45 protein enhances MST1-mediated apoptosis in vivo. Luo X, et al. Int J Mol Med, 2009 Mar. PMID 19212654.Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. Callus BA, et al. FEBS J, 2006 Sep. PMID 16930133.Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. Benzinger A, et al. Mol Cell Proteomics, 2005 Jun. PMID 15778465.The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Chan EH, et al. Oncogene, 2005 Mar 17. PMID 15688006.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
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