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SCN11A Antibody (monoclonal) (M04)

Mouse monoclonal antibody raised against a partial recombinant SCN11A.

  • WB - SCN11A Antibody (monoclonal) (M04) AT3791a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (33 KDa) .
  • E - SCN11A Antibody (monoclonal) (M04) AT3791a
    Detection limit for recombinant GST tagged SCN11A is approximately 0.03ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UI33
Other Accession NM_014139
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 60
Calculated MW 204922 Da
Additional Information
Gene ID 11280
Other Names Sodium channel protein type 11 subunit alpha, Peripheral nerve sodium channel 5, PN5, Sensory neuron sodium channel 2, Sodium channel protein type XI subunit alpha, Voltage-gated sodium channel subunit alpha Nav19, hNaN, SCN11A, SCN12A, SNS2
Target/Specificity SCN11A (NP_054858, 1726 a.a. ~ 1791 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSCN11A Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.


International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Catterall WA, et al. Pharmacol Rev, 2005 Dec. PMID 16382098.Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia. Raymond CK, et al. J Biol Chem, 2004 Oct 29. PMID 15302875.Na+ channel Nav1.9: in search of a gating mechanism. Delmas P, et al. Trends Neurosci, 2003 Feb. PMID 12536125.Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. Blum R, et al. Nature, 2002 Oct 17. PMID 12384689.Nomenclature of voltage-gated sodium channels. Goldin AL, et al. Neuron, 2000 Nov. PMID 11144347.

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$ 315.00
Cat# AT3791a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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