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SCN9A Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SCN9A.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q15858 |
| Other Accession | NM_002977 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 5A11 |
| Calculated MW | 226372 Da |
| Gene ID | 6335 |
|---|---|
| Other Names | Sodium channel protein type 9 subunit alpha, Neuroendocrine sodium channel, hNE-Na, Peripheral sodium channel 1, PN1, Sodium channel protein type IX subunit alpha, Voltage-gated sodium channel subunit alpha Nav17, SCN9A, NENA |
| Target/Specificity | SCN9A (NP_002968, 269 a.a. ~ 339 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SCN9A Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder.
References
Sodium channel Na v 1.7 immunoreactivity in painful human dental pulp and burning mouth syndrome. Beneng K, et al. BMC Neurosci, 2010 Jun 8. PMID 20529324. Alternative splicing may contribute to time-dependent manifestation of inherited erythromelalgia. Choi JS, et al. Brain, 2010 Jun. PMID 20478850. Mutations at opposite ends of the DIII/S4-S5 linker of sodium channel Na V 1.7 produce distinct pain disorders. Cheng X, et al. Mol Pain, 2010 Apr 29. PMID 20429905. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614. Pain perception is altered by a nucleotide polymorphism in SCN9A. Reimann F, et al. Proc Natl Acad Sci U S A, 2010 Mar 16. PMID 20212137.
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