SDHC Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SDHC.
|Application ||WB, IHC|
|Calculated MW||18610 Da|
|Other Names||Succinate dehydrogenase cytochrome b560 subunit, mitochondrial, Integral membrane protein CII-3, QPs-1, QPs1, Succinate dehydrogenase complex subunit C, Succinate-ubiquinone oxidoreductase cytochrome B large subunit, CYBL, SDHC, CYB560, SDH3|
|Target/Specificity||SDHC (AAH33626, 1 a.a. ~ 169 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SDHC Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described.
Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes. Gill AJ, et al. Hum Pathol, 2010 Jun. PMID 20236688.Relevance of germline mutation screening in both familial and sporadic head and neck paraganglioma for early diagnosis and clinical management. Hermsen MA, et al. Cell Oncol, 2010 Jan 1. PMID 20208144.Development and validation of a comprehensive mutation and deletion detection assay for SDHB, SDHC, and SDHD. Milosevic D, et al. Clin Biochem, 2010 May. PMID 20153743.Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas. Gaal J, et al. J Clin Endocrinol Metab, 2010 Mar. PMID 19915015.A role for succinate dehydrogenase genes in low chemoresponsiveness to hypoxia? Richalet JP, et al. Clin Auton Res, 2009 Dec. PMID 19768395.
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