SERPINI1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SERPINI1.
|Application ||WB, IHC, E|
|Calculated MW||46427 Da|
|Other Names||Neuroserpin, Peptidase inhibitor 12, PI-12, Serpin I1, SERPINI1, PI12|
|Target/Specificity||SERPINI1 (AAH18043, 17 a.a. ~ 410 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SERPINI1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
1.Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.Prunotto M, Farina A, Lane L, Pernin A, Schifferli J, Hochstrasser DF, Lescuyer P, Moll S.J Proteomics. 2013 Jan 30. doi:pii: S1874-3919(13)00040-7. 10.1016/j.jprot.2013.01.012. [Epub ahead of print]
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