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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SGCA Antibody (monoclonal) (M01)   

SGCA Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a partial recombinant SGCA.

  • WB - SGCA Antibody (monoclonal) (M01) AT3851a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.62 KDa) .
  • WB - SGCA Antibody (monoclonal) (M01) AT3851a
    Western Blot analysis of SGCA expression in transfected 293T cell line by SGCA monoclonal antibody (M01), clone 3C4.

    Lane 1: SGCA transfected lysate(42.9 KDa).
    Lane 2: Non-transfected lysate.
  • E - SGCA Antibody (monoclonal) (M01) AT3851a
    Detection limit for recombinant GST tagged SGCA is 1 ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16586
Other Accession NM_000023
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2b Kappa
Clone Names 3C4
Calculated MW 42875 Da
Additional Information
Gene ID 6442
Other Names Alpha-sarcoglycan, Alpha-SG, 50 kDa dystrophin-associated glycoprotein, 50DAG, Adhalin, Dystroglycan-2, SGCA, ADL, DAG2
Target/Specificity SGCA (NP_000014.1, 26 a.a. ~ 133 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSGCA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.


Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. Fernandez K, et al. Am J Pathol, 2010 Jan. PMID 20019182.Sarcoglycanopathies: can muscle immunoanalysis predict the genotype? Klinge L, et al. Neuromuscul Disord, 2008 Dec. PMID 18996010.Identification of two E-boxes that negatively modulate the activity of MyoD on the alpha-sarcoglycan core promoter. Delgado-Olgu?n P, et al. Biochim Biophys Acta, 2008 Jan. PMID 18078839.Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development. Rafii MS, et al. J Cell Physiol, 2006 Nov. PMID 16883602.Sarcoglycanopathies and the risk of undetected deletion alleles in diagnosis. White SJ, et al. Hum Mutat, 2005 Jul. PMID 15954112.

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$ 315.00
Cat# AT3851a
(40 western blots)
Availability: 7-10 days
Bulk Size
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