SGCA Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SGCA.
|Application ||WB, E|
|Calculated MW||42875 Da|
|Other Names||Alpha-sarcoglycan, Alpha-SG, 50 kDa dystrophin-associated glycoprotein, 50DAG, Adhalin, Dystroglycan-2, SGCA, ADL, DAG2|
|Target/Specificity||SGCA (NP_000014.1, 26 a.a. ~ 133 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SGCA Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a component of the dystrophin-glycoprotein complex (DGC), which is critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Its expression is thought to be restricted to striated muscle. Mutations in this gene result in type 2D autosomal recessive limb-girdle muscular dystrophy. Multiple transcript variants encoding different isoforms have been found for this gene.
Mice lacking dystrophin or alpha sarcoglycan spontaneously develop embryonal rhabdomyosarcoma with cancer-associated p53 mutations and alternatively spliced or mutant Mdm2 transcripts. Fernandez K, et al. Am J Pathol, 2010 Jan. PMID 20019182.Sarcoglycanopathies: can muscle immunoanalysis predict the genotype? Klinge L, et al. Neuromuscul Disord, 2008 Dec. PMID 18996010.Identification of two E-boxes that negatively modulate the activity of MyoD on the alpha-sarcoglycan core promoter. Delgado-Olgu?n P, et al. Biochim Biophys Acta, 2008 Jan. PMID 18078839.Biglycan binds to alpha- and gamma-sarcoglycan and regulates their expression during development. Rafii MS, et al. J Cell Physiol, 2006 Nov. PMID 16883602.Sarcoglycanopathies and the risk of undetected deletion alleles in diagnosis. White SJ, et al. Hum Mutat, 2005 Jul. PMID 15954112.
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