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SH3BP2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SH3BP2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P78314 |
| Other Accession | BC022996 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 1E10 |
| Calculated MW | 62244 Da |
| Gene ID | 6452 |
|---|---|
| Other Names | SH3 domain-binding protein 2, 3BP-2, SH3BP2, 3BP2 |
| Target/Specificity | SH3BP2 (AAH22996, 452 a.a. ~ 561 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SH3BP2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene.
References
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.NFATc1 and TNFalpha expression in giant cell lesions of the jaws. Amaral FR, et al. J Oral Pathol Med, 2010 Mar. PMID 20002873.Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFAT. Shukla U, et al. J Biol Chem, 2009 Dec 4. PMID 19833725.Novel mutations in the SH3BP2 gene associated with sporadic central giant cell lesions and cherubism. Carvalho VM, et al. Oral Dis, 2009 Jan. PMID 19017279.
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