SLA2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SLA2.
|Application ||WB, E|
|Calculated MW||28585 Da|
|Other Names||Src-like-adapter 2, Modulator of antigen receptor signaling, MARS, Src-like adapter protein 2, SLAP-2, SLA2, C20orf156, SLAP2|
|Target/Specificity||SLA2 (AAH42041, 1 a.a. ~ 261 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SLA2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene.
The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation. Pakuts B, et al. J Biol Chem, 2007 Jun 22. PMID 17353186.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.Cloning and characterization of human Src-like adaptor protein 2 and a novel splice isoform, SLAP-2-v. Loreto MP, et al. Oncogene, 2003 Jan 16. PMID 12527895.Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.
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