SLC33A1 Antibody (monoclonal) (M07)
Mouse monoclonal antibody raised against a partial recombinant SLC33A1.
|Application ||WB, E|
|Calculated MW||60909 Da|
|Other Names||Acetyl-coenzyme A transporter 1, AT-1, Acetyl-CoA transporter 1, Solute carrier family 33 member 1, SLC33A1, ACATN, AT1|
|Target/Specificity||SLC33A1 (NP_004724, 1 a.a. ~ 69 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SLC33A1 Antibody (monoclonal) (M07) is for research use only and not for use in diagnostic or therapeutic procedures.|
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The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene.
1.SLC33A1/AT-1 regulates the induction of autophagy down-stream of IRE1/XBP1.Pehar M, Jonas MC, Hare TM, Puglielli L.J Biol Chem. 2012 Jul 11.2.AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability.Jonas MC, Pehar M, Puglielli L.J Cell Sci. 2010 Oct 1;123(Pt 19):3378-88. Epub 2010 Sep 7.
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