SLC4A4 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SLC4A4.
|Application ||WB, E|
|Calculated MW||121461 Da|
|Other Names||Electrogenic sodium bicarbonate cotransporter 1, Sodium bicarbonate cotransporter, Na(+)/HCO3(-) cotransporter, Solute carrier family 4 member 4, kNBC1, SLC4A4, NBC, NBC1, NBCE1|
|Target/Specificity||SLC4A4 (AAH30977, 1 a.a. ~ 646 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SLC4A4 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Topological location and structural importance of the NBCe1-A residues mutated in proximal renal tubular acidosis. Zhu Q, et al. J Biol Chem, 2010 Apr 30. PMID 20197274.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results. Dorfman R, et al. Hum Genet, 2009 Aug 7. PMID 19662435.Mutation of Aspartate 555 of the Sodium/Bicarbonate Transporter SLC4A4/NBCe1 Induces Chloride Transport. Yang HS, et al. J Biol Chem, 2009 Jun 5. PMID 19336397.
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