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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SLC6A4 Antibody (monoclonal) (M06)   

SLC6A4 Antibody (monoclonal) (M06)

Mouse monoclonal antibody raised against a partial recombinant SLC6A4.

  • E - SLC6A4 Antibody (monoclonal) (M06) AT3931a
    Detection limit for recombinant GST tagged SLC6A4 is approximately 0.3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P31645
Other Accession NM_001045
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 2A9
Calculated MW 70325 Da
Additional Information
Gene ID 6532
Other Names Sodium-dependent serotonin transporter, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4, HTT, SERT
Target/Specificity SLC6A4 (NP_001036, 181 a.a. ~ 252 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsSLC6A4 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.


Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. Blaya C, et al. Neurosci Lett, 2010 Sep 10. PMID 20817074.Serotonin transporter polymorphism as a predictor for escitalopram treatment of major depressive disorder comorbid with alcohol dependence. Muhonen LH, et al. Psychiatry Res, 2010 Aug 26. PMID 20800901.Evidence for plasticity genotypes in a gene-gene-environment interaction: the TRAILS study. Nederhof E, et al. Genes Brain Behav, 2010 Aug 4. PMID 20738408.[Interaction effect of serotonin transporter gene and brain-derived neurotrophic factor on the platelet serotonin content in stroke patients] . Zh Nevrol Psikhiatr Im S S Korsakova, 2010. PMID 20738025.Association between serotonin transporter polymorphisms and problem behavior in adult males with intellectual disabilities. May ME, et al. Brain Res, 2010 Aug 21. PMID 20735998.

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$ 315.00
Cat# AT3931a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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