SLC6A4 Antibody (monoclonal) (M06)
Mouse monoclonal antibody raised against a partial recombinant SLC6A4.
|Calculated MW||70325 Da|
|Other Names||Sodium-dependent serotonin transporter, 5HT transporter, 5HTT, Solute carrier family 6 member 4, SLC6A4, HTT, SERT|
|Target/Specificity||SLC6A4 (NP_001036, 181 a.a. ~ 252 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SLC6A4 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. Blaya C, et al. Neurosci Lett, 2010 Sep 10. PMID 20817074.Serotonin transporter polymorphism as a predictor for escitalopram treatment of major depressive disorder comorbid with alcohol dependence. Muhonen LH, et al. Psychiatry Res, 2010 Aug 26. PMID 20800901.Evidence for plasticity genotypes in a gene-gene-environment interaction: the TRAILS study. Nederhof E, et al. Genes Brain Behav, 2010 Aug 4. PMID 20738408.[Interaction effect of serotonin transporter gene and brain-derived neurotrophic factor on the platelet serotonin content in stroke patients] . Zh Nevrol Psikhiatr Im S S Korsakova, 2010. PMID 20738025.Association between serotonin transporter polymorphisms and problem behavior in adult males with intellectual disabilities. May ME, et al. Brain Res, 2010 Aug 21. PMID 20735998.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.