SOCS5 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SOCS5.
|Application ||WB, IHC, E|
|Calculated MW||61246 Da|
|Other Names||Suppressor of cytokine signaling 5, SOCS-5, Cytokine-inducible SH2 protein 6, CIS-6, Cytokine-inducible SH2-containing protein 5, SOCS5, CIS6, CISH5, CISH6, KIAA0671|
|Target/Specificity||SOCS5 (AAH32862, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SOCS5 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.
The control of allergic conjunctivitis by suppressor of cytokine signaling (SOCS)3 and SOCS5 in a murine model. Ozaki A, et al. J Immunol, 2005 Oct 15. PMID 16210657.Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling. Nicholson SE, et al. Proc Natl Acad Sci U S A, 2005 Feb 15. PMID 15695332.Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling. Kario E, et al. J Biol Chem, 2005 Feb 25. PMID 15590694.The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.Identification of NPM-ALK interacting proteins by tandem mass spectrometry. Crockett DK, et al. Oncogene, 2004 Apr 8. PMID 14968112.
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