SOX3 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant SOX3.
|Calculated MW||45210 Da|
|Other Names||Transcription factor SOX-3, SOX3|
|Target/Specificity||SOX3 (NP_005625, 375 a.a. ~ 446 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SOX3 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.
Mutation and gene copy number analyses of six pituitary transcription factor genes in 71 patients with combined pituitary hormone deficiency: identification of a single patient with LHX4 deletion. Dateki S, et al. J Clin Endocrinol Metab, 2010 Aug. PMID 20534763.The male-determining gene SRY is a hybrid of DGCR8 and SOX3, and is regulated by the transcription factor CP2. Sato Y, et al. Mol Cell Biochem, 2010 Apr. PMID 19902333.PBX1 and MEIS1 up-regulate SOX3 gene expression by direct interaction with a consensus binding site within the basal promoter region. Mojsin M, et al. Biochem J, 2009 Dec 14. PMID 19799567.Brachymesomelic dysplasia with Peters anomaly of the eye results from disruptions of the X chromosome near the SHOX and SOX3 genes. Bleyl SB, et al. Am J Med Genet A, 2007 Dec 1. PMID 17994562.Regulation of SOX3 gene expression is driven by multiple NF-Y binding elements. Krstic A, et al. Arch Biochem Biophys, 2007 Nov 15. PMID 17910945.
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