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SPIRE1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant SPIRE1.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q08AE8 |
| Other Accession | NM_020148 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 4C5 |
| Calculated MW | 85544 Da |
| Gene ID | 56907 |
|---|---|
| Other Names | Protein spire homolog 1, Spir-1, SPIRE1 {ECO:0000312|EMBL:AAI252071}, KIAA1135, SPIR1 |
| Target/Specificity | SPIRE1 (NP_064533, 482 a.a. ~ 583 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SPIRE1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Spire proteins, such as SPIRE1, are highly conserved between species. They belong to the family of Wiskott-Aldrich homology region-2 (WH2) proteins, which are involved in actin organization (Kerkhoff et al., 2001 [PubMed 11747823]).
References
1.Annexin A2-Dependent Polymerization of Actin Mediates Endosome Biogenesis.Morel E, Parton RG, Gruenberg J.Dev Cell. 2009 Mar;16(3):445-57.2.Actin S-Nitrosylation Inhibits Neutrophil {beta}2 Integrin Function.Thom SR, Bhopale VM, Mancini DJ, Milovanova TN.J Biol Chem. 2008 Apr 18;283(16):10822-34. Epub 2008 Feb 18.
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