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SSB Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant SSB.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | P05455 |
| Other Accession | BC001289 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 kappa |
| Clone Names | 1D6-H5 |
| Calculated MW | 46837 Da |
| Gene ID | 6741 |
|---|---|
| Other Names | Lupus La protein, La autoantigen, La ribonucleoprotein, Sjoegren syndrome type B antigen, SS-B, SSB |
| Target/Specificity | SSB (AAH01289, 1 a.a. ~ 408 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SSB Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).
References
1.Phosphorylation of human La protein at Ser366 by casein kinase II contributes to hepatitis B virus replication and expression in vitro.Tang J, Zhang ZH, Huang M, Heise T, Zhang J, Liu GL.Journal of Viral Hepatitis, 2012 doi:10.1111/ j.1365-2893.2012.01636.x2.Akt phosphorylation of La regulates specific mRNA translation in glial progenitors.Brenet F, Socci ND, Sonenberg N, Holland EC.Oncogene. 2009 Jan 8;28(1):128-39. Epub 2008 Oct 6.
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