SUGT1 Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant SUGT1.
|Application ||WB, IF, E|
|Calculated MW||41024 Da|
|Other Names||Suppressor of G2 allele of SKP1 homolog, Protein 40-6-3, Sgt1, SUGT1|
|Target/Specificity||SUGT1 (NP_006695, 151 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||SUGT1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions. Two transcript variants encoding different isoforms have been found for this gene.
Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. Davies AE, et al. J Cell Biol, 2010 Apr 19. PMID 20404110.Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.Sgt1 dimerization is negatively regulated by protein kinase CK2-mediated phosphorylation at Ser361. Bansal PK, et al. J Biol Chem, 2009 Jul 10. PMID 19398558.Sgt1 has co-chaperone properties and is up-regulated by heat shock. Zabka M, et al. Biochem Biophys Res Commun, 2008 May 23. PMID 18358234.Hsp70 is a new target of Sgt1--an interaction modulated by S100A6. Spiechowicz M, et al. Biochem Biophys Res Commun, 2007 Jun 15. PMID 17466273.
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