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SUMF2 Antibody (monoclonal) (M02)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT4104a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
SUMF2 Antibody (monoclonal) (M02) - Product info | |
| Application | WB
|
| Primary Accession | Q8NBJ7 |
| Other Accession | NP_056226 |
| Reactivity | Human |
| Isotype | IgG2a Kappa |
| Clone Names | 4B3 |
| Calculated MW | 33843 Da |
SUMF2 Antibody (monoclonal) (M02) - Additional info | |
| Gene ID 25870 | |
| Other Names DKFZp66I1024, MGC99485sulfatase modifying factor 2 | |
| Target/Specificity SUMF2 (NP_056226, 26 a.a. ~ 126 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions SUMF2 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. | |
SUMF2 Antibody (monoclonal) (M02) - Application data
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SUMF2 monoclonal antibody (M02), clone 4B3 Western Blot analysis of SUMF2 expression in A-431 ( Cat # L015V1 ).
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Detection limit for recombinant GST tagged SUMF2 is approximately 3ng/ml as a capture antibody.
SUMF2 Antibody (monoclonal) (M02) - Related products
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BACKGROUND
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
REFERENCES
SUMF2 interacts with interleukin-13 and inhibits interleukin-13 secretion in bronchial smooth muscle cells. Liang H, et al. J Cell Biochem, 2009 Dec 1. PMID 19739097.Paralog of the formylglycine-generating enzyme--retention in the endoplasmic reticulum by canonical and noncanonical signals. Gande SL, et al. FEBS J, 2008 Mar. PMID 18266766.Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. Otsuki T, et al. DNA Res, 2005. PMID 16303743.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.
