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TARBP2 Antibody (monoclonal) (M04)
Mouse monoclonal antibody raised against a partial recombinant TARBP2.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q15633 |
| Other Accession | NM_134323 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 2G10 |
| Calculated MW | 39039 Da |
| Gene ID | 6895 |
|---|---|
| Other Names | RISC-loading complex subunit TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}, TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein, TARBP2 {ECO:0000255|HAMAP-Rule:MF_03034}, TRBP |
| Target/Specificity | TARBP2 (NP_599150, 141 a.a. ~ 250 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TARBP2 Antibody (monoclonal) (M04) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.
References
Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan. Boni V, et al. Pharmacogenomics J, 2010 Jun 29. PMID 20585341. Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes. Wilker EH, et al. Environ Health Perspect, 2010 Jul. PMID 20211803. Structure of the human Dicer-TRBP complex by electron microscopy. Lau PW, et al. Structure, 2009 Oct 14. PMID 19836333. Structural insights into RNA processing by the human RISC-loading complex. Wang HW, et al. Nat Struct Mol Biol, 2009 Nov. PMID 19820710. Characterization of the TRBP domain required for dicer interaction and function in RNA interference. Daniels SM, et al. BMC Mol Biol, 2009 May 7. PMID 19422693.
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