TAX1BP1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TAX1BP1.
|Application ||WB, E|
|Calculated MW||90877 Da|
|Other Names||Tax1-binding protein 1, TRAF6-binding protein, TAX1BP1, T6BP|
|Target/Specificity||TAX1BP1 (NP_006015, 690 a.a. ~ 789 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TAX1BP1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The HTLV-1 Tax protein transcriptionally activates the HTLV-1 promoter. Tax also binds to and stimulates the expression of cellular genes, including transcription factors and other proteins (Gachon et al., 1998 [PubMed 9733879]).
Analysis of the TAX1BP1 gene in head and neck cancer patients. Ruiz MT, et al. Braz J Otorhinolaryngol, 2010 Apr. PMID 20549079.TAX1BP1 and A20 inhibit antiviral signaling by targeting TBK1-IKKi kinases. Parvatiyar K, et al. J Biol Chem, 2010 May 14. PMID 20304918.Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. Shembade N, et al. Science, 2010 Feb 26. PMID 20185725.The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling. Shembade N, et al. EMBO J, 2009 Mar 4. PMID 19131965.Genetic variation in the nuclear factor kappaB pathway in relation to susceptibility to rheumatoid arthritis. Dieguez-Gonzalez R, et al. Ann Rheum Dis, 2009 Apr. PMID 18434448.
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