TAZ Antibody (monoclonal) (M19)
Mouse monoclonal antibody raised against a full length recombinant TAZ.
|Application ||IF, E|
|Calculated MW||33459 Da|
|Other Names||Tafazzin, Protein G45, TAZ, EFE2, G45|
|Target/Specificity||TAZ (AAH11515, 1 a.a. ~ 262 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TAZ Antibody (monoclonal) (M19) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a protein that is expressed at high levels in cardiac and skeletal muscle. Mutations in this gene have been associated with a number of clinical disorders including Barth syndrome, dilated cardiomyopathy (DCM), hypertrophic DCM, endocardial fibroelastosis, and left ventricular noncompaction (LVNC). Multiple transcript variants encoding different isoforms have been described. A long form and a short form of each of these isoforms is produced; the short form lacks a hydrophobic leader sequence and may exist as a cytoplasmic protein rather than being membrane-bound. Other alternatively spliced transcripts have been described but the full-length nature of all these transcripts is not known.
A novel custom resequencing array for dilated cardiomyopathy. Zimmerman RS, et al. Genet Med, 2010 May. PMID 20474083.Human transcriptional coactivator with PDZ-binding motif (TAZ) is downregulated during decidualization. Strakova Z, et al. Biol Reprod, 2010 Jun. PMID 20164440.Characterization of tafazzin splice variants from humans and fruit flies. Xu Y, et al. J Biol Chem, 2009 Oct 16. PMID 19700766.Mutations in TAZ/WWTR1, a co-activator of NKX2.1 and PAX8 are not a frequent cause of thyroid dysgenesis. Ferrara AM, et al. J Endocrinol Invest, 2009 Mar. PMID 19542741.TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. Zhang H, et al. J Biol Chem, 2009 May 15. PMID 19324877.
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