TCL1A Antibody (monoclonal) (M12)
Mouse monoclonal antibody raised against a partial recombinant TCL1A.
|Calculated MW||13460 Da|
|Other Names||T-cell leukemia/lymphoma protein 1A, Oncogene TCL-1, Oncogene TCL1, Protein p14 TCL1, TCL1A, TCL1|
|Target/Specificity||TCL1A (NP_068801.1, 61 a.a. ~ 114 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TCL1A Antibody (monoclonal) (M12) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Overexpression of the TCL1 gene in humans has been implicated in the development of mature T cell leukemia, in which chromosomal rearrangements bring the TCL1 gene in close proximity to the T-cell antigen receptor (TCR)-alpha (MIM 186880) or TCR-beta (MIM 186930) regulatory elements (summarized by Virgilio et al., 1998 [PubMed 9520462]). In normal T cells TCL1 is expressed in CD4-/CD8- cells, but not in cells at later stages of differentiation. TCL1 functions as a coactivator of the cell survival kinase AKT (MIM 164730) (Laine et al., 2000 [PubMed 10983986]).
TCL1 protein expression in testicular germ cell tumors. Lau SK, et al. Am J Clin Pathol, 2010 May. PMID 20395523.T-cell leukemia 1 expression in nodal Epstein-Barr virus-negative diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. Gualco G, et al. Hum Pathol, 2010 Sep. PMID 20382409.Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.CD5+CD23+ leukemic cell populations in TCL1 transgenic mice show significantly increased proliferation and Akt phosphorylation. Efanov A, et al. Leukemia, 2010 May. PMID 20357824.IGHV3-21 gene usage is associated with high TCL1 expression in chronic lymphocytic leukemia. Mansouri MR, et al. Eur J Haematol, 2010 Feb 1. PMID 19889012.
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