TFPI2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant TFPI2.
|Application ||WB, IHC, E|
|Calculated MW||26934 Da|
|Other Names||Tissue factor pathway inhibitor 2, TFPI-2, Placental protein 5, PP5, TFPI2|
|Target/Specificity||TFPI2 (AAH05330, 1 a.a. ~ 235 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TFPI2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Tissue factor pathway inhibitor-2 is induced by fluid shear stress in vascular smooth muscle cells and affects cell proliferation and survival. Ekstrand J, et al. J Vasc Surg, 2010 Jul. PMID 20537494.Methylation of TFPI2 gene is frequently detected in advanced well-differentiated colorectal cancer. Hibi K, et al. Anticancer Res, 2010 Apr. PMID 20530429.A novel role for tissue factor pathway inhibitor-2 in the therapy of human esophageal carcinoma. Ran Y, et al. Hum Gene Ther, 2009 Jan. PMID 20377370.Epigenetic inactivation of the placentally imprinted tumor suppressor gene TFPI2 in prostate carcinoma. Ribarska T, et al. Cancer Genomics Proteomics, 2010 Mar-Apr. PMID 20335518.Tissue factor pathway inhibitor 2 (TFPI2) is frequently silenced by aberrant promoter hypermethylation in gastric cancer. Takada H, et al. Cancer Genet Cytogenet, 2010 Feb. PMID 20113832.
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