TNFRSF19L Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant TNFRSF19L.
|Application ||WB, E|
|Calculated MW||46092 Da|
|Other Names||Tumor necrosis factor receptor superfamily member 19L, Receptor expressed in lymphoid tissues, RELT, TNFRSF19L|
|Target/Specificity||TNFRSF19L (NP_116260, 26 a.a. ~ 124 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TNFRSF19L Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1 (TRAF1). This receptor is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
RELT induces cellular death in HEK 293 epithelial cells. Cusick JK, et al. Cell Immunol, 2010. PMID 19969290.TRAIL-induced cleavage and inactivation of SPAK sensitizes cells to apoptosis. Polek TC, et al. Biochem Biophys Res Commun, 2006 Oct 27. PMID 16950202.Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. Bossen C, et al. J Biol Chem, 2006 May 19. PMID 16547002.The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. Polek TC, et al. Biochem Biophys Res Commun, 2006 Apr 28. PMID 16530727.Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. Cusick JK, et al. Biochem Biophys Res Commun, 2006 Feb 10. PMID 16389068.
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