TOPORS Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant TOPORS.
|Application ||WB, IF, E|
|Calculated MW||119198 Da|
|Other Names||E3 ubiquitin-protein ligase Topors, 632-, SUMO1-protein E3 ligase Topors, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Tumor suppressor p53-binding protein 3, p53-binding protein 3, p53BP3, TOPORS, LUN, TP53BPL|
|Target/Specificity||TOPORS (NP_005793, 98 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||TOPORS Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Plk1-mediated phosphorylation of Topors regulates p53 stability. Yang X, et al. J Biol Chem, 2009 Jul 10. PMID 19473992.Mutations in TOPORS: a rare cause of autosomal dominant retinitis pigmentosa in continental Europe? Schob C, et al. Ophthalmic Genet, 2009 Jun. PMID 19373681.Autosomal dominant pericentral retinal dystrophy caused by a novel missense mutation in the TOPORS gene. Selmer KK, et al. Acta Ophthalmol, 2010 May. PMID 19183411.Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity. Park HJ, et al. Biochemistry, 2008 Dec 30. PMID 19053840.
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