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TOPORS Antibody (monoclonal) (M02)

Mouse monoclonal antibody raised against a partial recombinant TOPORS.

  • WB - TOPORS Antibody (monoclonal) (M02) AT4309a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.62 KDa) .
  • IF - TOPORS Antibody (monoclonal) (M02) AT4309a
    Immunofluorescence of monoclonal antibody to TOPORS on HeLa cell . [antibody concentration 10 ug/ml]
  • E - TOPORS Antibody (monoclonal) (M02) AT4309a
    Detection limit for recombinant GST tagged TOPORS is approximately 1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NS56
Other Accession NM_005802
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4G4
Calculated MW 119198 Da
Additional Information
Gene ID 10210
Other Names E3 ubiquitin-protein ligase Topors, 632-, SUMO1-protein E3 ligase Topors, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Tumor suppressor p53-binding protein 3, p53-binding protein 3, p53BP3, TOPORS, LUN, TP53BPL
Target/Specificity TOPORS (NP_005793, 98 a.a. ~ 205 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTOPORS Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.


Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.Plk1-mediated phosphorylation of Topors regulates p53 stability. Yang X, et al. J Biol Chem, 2009 Jul 10. PMID 19473992.Mutations in TOPORS: a rare cause of autosomal dominant retinitis pigmentosa in continental Europe? Schob C, et al. Ophthalmic Genet, 2009 Jun. PMID 19373681.Autosomal dominant pericentral retinal dystrophy caused by a novel missense mutation in the TOPORS gene. Selmer KK, et al. Acta Ophthalmol, 2010 May. PMID 19183411.Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity. Park HJ, et al. Biochemistry, 2008 Dec 30. PMID 19053840.

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$ 315.00
Cat# AT4309a
(40 western blots)
Availability: 7-10 days
Bulk Size
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