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TRIM16 Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a partial recombinant TRIM16.
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Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.73 KDa) .
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TRIM16 monoclonal antibody (M02), clone 5G11 Western Blot analysis of TRIM16 expression in Jurkat ( (Cat # AT4342a )
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Immunoperoxidase of monoclonal antibody to TRIM16 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]
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Detection limit for recombinant GST tagged TRIM16 is approximately 0.03ng/ml as a capture antibody.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | O95361 |
| Other Accession | NM_006470 |
| Reactivity | Human |
| Host | mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 5G11 |
| Calculated MW | 63955 Da |
| Gene ID | 10626 |
|---|---|
| Other Names | Tripartite motif-containing protein 16, Estrogen-responsive B box protein, TRIM16, EBBP |
| Target/Specificity | TRIM16 (NP_006461, 165 a.a. ~ 273 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TRIM16 Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.
References
The estrogen-responsive B box protein (EBBP) restores retinoid sensitivity in retinoid-resistant cancer cells via effects on histone acetylation. Raif A, et al. Cancer Lett, 2009 May 8. PMID 19147277.The estrogen-responsive B box protein is a novel regulator of the retinoid signal. Cheung BB, et al. J Biol Chem, 2006 Jun 30. PMID 16636064.The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. Munding C, et al. Cell Death Differ, 2006 Nov. PMID 16575408.A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.Differential gene expression in normal human mammary epithelial cells treated with malathion monitored by DNA microarrays. Gwinn MR, et al. Environ Health Perspect, 2005 Aug. PMID 16079077.
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