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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   TRIM5 Antibody (monoclonal) (M06)   

TRIM5 Antibody (monoclonal) (M06)

Mouse monoclonal antibody raised against a partial recombinant TRIM5.

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9C035
Other Accession NM_033034
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 2A6
Calculated MW 56338 Da
Additional Information
Gene ID 85363
Other Names Tripartite motif-containing protein 5, 632-, RING finger protein 88, TRIM5, RNF88
Target/Specificity TRIM5 (NP_149023, 309 a.a. ~ 418 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTRIM5 Antibody (monoclonal) (M06) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.


Murine double minute 2 as a modulator of retroviral restrictions mediated by TRIM5alpha. Malbec M, et al. Virology, 2010 Sep 30. PMID 20619429.A TRIM5alpha exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort. Price H, et al. AIDS, 2010 Jul 31. PMID 20588169.p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. O'Connor C, et al. J Virol, 2010 Jun. PMID 20357094.Hsp70 interacts with the retroviral restriction factor TRIM5alpha and assists the folding of TRIM5alpha. Hwang CY, et al. J Biol Chem, 2010 Mar 5. PMID 20053985.Anti-retroviral activity of TRIM5 alpha. Nakayama EE, et al. Rev Med Virol, 2010 Mar. PMID 20049904.

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$ 315.00
Cat# AT4358a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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