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TTR Antibody (monoclonal) (M01)

Mouse monoclonal antibody raised against a full length recombinant TTR.

  • WB - TTR Antibody (monoclonal) (M01) AT4395a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (39.71 KDa) .
  • WB - TTR Antibody (monoclonal) (M01) AT4395a
    Western Blot analysis of TTR expression in transfected 293T cell line by TTR monoclonal antibody (M01), clone 4D8.

    Lane 1: TTR transfected lysate(15.9 KDa).
    Lane 2: Non-transfected lysate.
  • E - TTR Antibody (monoclonal) (M01) AT4395a
    Detection limit for recombinant GST tagged TTR is approximately 1ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02766
Other Accession BC020791
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1 Kappa
Clone Names 4D8
Calculated MW 15887 Da
Additional Information
Gene ID 7276
Other Names Transthyretin, ATTR, Prealbumin, TBPA, TTR, PALB
Target/Specificity TTR (AAH20791.1, 21 a.a. ~ 147 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsTTR Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.


Clinical presentations and skin denervation in amyloid neuropathy due to transthyretin Ala97Ser. Yang NC, et al. Neurology, 2010 Aug 10. PMID 20697105.Progression of transthyretin amyloid neuropathy after liver transplantation. Liepnieks JJ, et al. Neurology, 2010 Jul 27. PMID 20660862.Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin. Martinho A, et al. FEBS J, 2010 Aug. PMID 20646067.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Serum transthyretin levels in Swedish TTR V30M carriers. Buxbaum J, et al. Amyloid, 2010 Jun. PMID 20462367.

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$ 315.00
Cat# AT4395a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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