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TYMS Antibody (monoclonal) (M01)Purified Mouse Monoclonal Antibody (Mab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AT4425a | 100 ug 400 ul | 7-10 days | $ 315.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
TYMS Antibody (monoclonal) (M01) - Product info | |
| Application | IF, WB
|
| Primary Accession | P04818 |
| Reactivity | Human |
| Isotype | IgG1 Kappa |
| Clone Names | 3A1 |
| Calculated MW | 35716 Da |
TYMS Antibody (monoclonal) (M01) - Additional info | |
| Gene ID 7298 | |
| Other Names HsT422, MGC88736, TMS, TS, TSasethymidylate synthetase | |
| Target/Specificity TYMS (AAH13919, 111 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. | |
| Dilution WB~~1:500~1000 | |
| Format Clear, colorless solution in phosphate buffered saline, pH 7.2 . | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions TYMS Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. | |
TYMS Antibody (monoclonal) (M01) - Related products
AP6682b: TYSY Antibody (C-term)
AP6682c: TYSY Antibody (Center)
BP6682b: TYSY Antibody (C-term) Blocking Peptide
TYMS Antibody (monoclonal) (M01) - Application data
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Immunofluorescence of monoclonal antibody to TYMS (AT4425a) on HeLa cell . [antibody concentration 20 ug/ml]
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TYMS monoclonal antibody (M01), clone 3A1 Western Blot analysis of TYMS expression in HeLa ( Cat # L013V1 ).
TYMS Antibody (monoclonal) (M01) - Research Areas
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BACKGROUND
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.
REFERENCES
Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients. Kristensen MH, et al. J Int Med Res, 2010 May-Jun. PMID 20819423.Genetic polymorphisms associated with 5-Fluorouracil-induced neurotoxicity. Kim SR, et al. Chemotherapy, 2010. PMID 20714149.Association of genetic variation in cystathionine-beta-synthase and arsenic metabolism. Porter KE, et al. Environ Res, 2010 Aug. PMID 20670920.Value of gene polymorphisms as markers of 5-FU therapy response in stage III colon carcinoma: a pilot study. Fari?a-Sarasqueta A, et al. Cancer Chemother Pharmacol, 2010 Jul 28. PMID 20665215.Polymorphisms of thymidylate synthase gene 5'- and 3'-untranslated region and risk of gastric cancer in Koreans. Yim DJ, et al. Anticancer Res, 2010 Jun. PMID 20651387.
