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UCP1 Antibody (monoclonal) (M03)

Mouse monoclonal antibody raised against a partial recombinant UCP1.

  • WB - UCP1 Antibody (monoclonal) (M03) AT4459a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (29.7 KDa) .
  • WB - UCP1 Antibody (monoclonal) (M03) AT4459a
    UCP1 monoclonal antibody (M03), clone 4B7. Western Blot analysis of UCP1 expression in NIH/3T3 ( (Cat # AT4459a )
  • E - UCP1 Antibody (monoclonal) (M03) AT4459a
    Detection limit for recombinant GST tagged UCP1 is approximately 3ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P25874
Other Accession NM_021833
Reactivity Human, Mouse
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 4B7
Calculated MW 33005 Da
Additional Information
Gene ID 7350
Other Names Mitochondrial brown fat uncoupling protein 1, UCP 1, Solute carrier family 25 member 7, Thermogenin, UCP1, SLC25A7, UCP
Target/Specificity UCP1 (NP_068605, 232 a.a. ~ 267 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsUCP1 Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.


The Effects of Uncoupling Protein 1 and beta3-Adrenergic Receptor Gene Polymorphisms on Weight Loss and Lipid Profiles in Obese Women. Kim JY, et al. Int J Vitam Nutr Res, 2010 Mar. PMID 20803423.Population Genetic Analysis of the Uncoupling Proteins Supports a Role for UCP3 in Human Cold Resistance. Hancock AM, et al. Mol Biol Evol, 2010 Aug 28. PMID 20802238.Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Large copy number variations are enriched in cases with moderate to extreme obesity. Wang K, et al. Diabetes, 2010 Jul 9. PMID 20622171.Association study of 182 candidate genes in anorexia nervosa. Pinheiro AP, et al. Am J Med Genet B Neuropsychiatr Genet, 2010 Jul. PMID 20468064.

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$ 315.00
Cat# AT4459a
(40 western blots)
Availability: 7-10 days
Bulk Size
Seasonal Special on Bulk Order
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