UNC119 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant UNC119.
|Application ||WB, IP|
|Calculated MW||26962 Da|
|Other Names||Protein unc-119 homolog A, Retinal protein 4, hRG4, UNC119, RG4|
|Target/Specificity||UNC119 (AAH27176.1, 1 a.a. ~ 240 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||UNC119 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene.
Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma. Gorska MM, et al. J Immunol, 2010 Apr 15. PMID 20220094.UNC119 inhibits dynamin and dynamin-dependent endocytic processes. Karim Z, et al. Cell Signal, 2010 Jan. PMID 19781630.Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation. Gorska MM, et al. J Immunol, 2009 Aug 1. PMID 19592652.Unc119 regulates myofibroblast differentiation through the activation of Fyn and the p38 MAPK pathway. Vepachedu R, et al. J Immunol, 2007 Jul 1. PMID 17579091.Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674.
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