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UNC13D Antibody (monoclonal) (M05)

Mouse monoclonal antibody raised against a partial recombinant UNC13D.

  • WB - UNC13D Antibody (monoclonal) (M05) AT4470a
    Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.41 KDa) .
  • WB - UNC13D Antibody (monoclonal) (M05) AT4470a
    UNC13D monoclonal antibody (M05), clone 2C7. Western Blot analysis of UNC13D expression in Jurkat ( (Cat # AT4470a )
  • E - UNC13D Antibody (monoclonal) (M05) AT4470a
    Detection limit for recombinant GST tagged UNC13D is 0.3 ng/ml as a capture antibody.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q70J99
Other Accession NM_199242
Reactivity Human
Host mouse
Clonality Monoclonal
Isotype IgG2a Kappa
Clone Names 2C7
Calculated MW 123282 Da
Additional Information
Gene ID 201294
Other Names Protein unc-13 homolog D, Munc13-4, UNC13D
Target/Specificity UNC13D (NP_954712.1, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Dilution WB~~1:500~1000
Format Clear, colorless solution in phosphate buffered saline, pH 7.2 .
StorageStore at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
PrecautionsUNC13D Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.


UNC13D is the predominant causative gene with recurrent splicing mutations in Korean patients with familial hemophagocytic lymphohistiocytosis. Yoon HS, et al. Haematologica, 2010 Apr. PMID 20015888.Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Wood SM, et al. Blood, 2009 Nov 5. PMID 19704116.Neonatal primary hemophagocytic lymphohistiocytosis in Turkish children. Gurgey A, et al. J Pediatr Hematol Oncol, 2008 Dec. PMID 19131769.Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Beutler B. Immunol Rev, 2009 Jan. PMID 19120489.Macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis is associated with MUNC13-4 polymorphisms. Zhang K, et al. Arthritis Rheum, 2008 Sep. PMID 18759271.

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$ 315.00
Cat# AT4470a
(40 western blots)
Availability: 7-10 days
Bulk Size
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