VDAC2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full-length recombinant VDAC2.
|Application ||WB, IF, E|
|Calculated MW||31567 Da|
|Other Names||Voltage-dependent anion-selective channel protein 2, VDAC-2, hVDAC2, Outer mitochondrial membrane protein porin 2, VDAC2|
|Target/Specificity||VDAC2 (AAH00165, 1 a.a. ~ 294 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Format||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.|
|Precautions||VDAC2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants.
Characterization of human VDAC isoforms: A peculiar function for VDAC3? De Pinto V, et al. Biochim Biophys Acta, 2010 Jun-Jul. PMID 20138821.Expression and localization of voltage-dependent anion channels (VDAC) in human spermatozoa. Liu B, et al. Biochem Biophys Res Commun, 2009 Jan 16. PMID 19013129.VDAC2 and aldolase A identified as membrane proteins of K562 cells with increased expression under iron deprivation. Valis K, et al. Mol Cell Biochem, 2008 Apr. PMID 18278581.The layered structure of human mitochondrial DNA nucleoids. Bogenhagen DF, et al. J Biol Chem, 2008 Feb 8. PMID 18063578.High-level expression, refolding and probing the natural fold of the human voltage-dependent anion channel isoforms I and II. Engelhardt H, et al. J Membr Biol, 2007 Apr. PMID 17828567.
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