|Application ||WB, FC, IHC-P|
|Calculated MW||H=39,31;M=39;Rat=40 KDa|
|Antigen Region||203-238 aa|
|Other Names||DNA fragmentation factor subunit beta, 3---, Caspase-activated deoxyribonuclease, CAD, Caspase-activated DNase, Caspase-activated nuclease, CPAN, DNA fragmentation factor 40 kDa subunit, DFF-40, DFFB, CAD, DFF2, DFF40|
|Target/Specificity||This DFFB antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 203-238 amino acids from the Central region of human DFFB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DFFB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||CAD, DFF2, DFF40|
|Function||Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.|
|Cellular Location||Cytoplasm. Nucleus.|
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Provided below are standard protocols that you may find useful for product applications.
Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology.
Liu X.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:8461-8466(1998).
Mukae N.,et al.Proc. Natl. Acad. Sci. U.S.A. 95:9123-9128(1998).
Halenbeck R.,et al.Curr. Biol. 8:537-540(1998).
Nakagawara A.,et al.Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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