|Application ||WB, IHC-P|
|Calculated MW||H=59,44 KDa|
|Antigen Region||484-514 aa|
|Other Names||OASL; TRIP14; 2'-5'-oligoadenylate synthase-like protein; 2'-5'-OAS-related protein; 59 kDa 2'-5'-oligoadenylate synthase-like protein; Thyroid receptor-interacting protein 14; p59 OASL|
|Target/Specificity||This OASL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-514 amino acids from the C-terminal region of human OASL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||OASL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.|
|Cellular Location||Isoform p56: Nucleus, nucleolus. Cytoplasm.|
|Tissue Location||Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis|
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Provided below are standard protocols that you may find useful for product applications.
2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted 514-amino acid human p59OASL (2-5A synthetases-like) protein shares a highly conserved N-terminal domain with other OASs. The C-terminal portion of p59OASL contains 2 ubiquitin-like domains. p59OASL is expressed in most tissues, with the highest levels in hematopoietic tissues, colon, and stomach.
Hovnanian, A., et al., Genomics 56(3):362-363 (1999).
Rebouillat, D., et al., Eur. J. Biochem. 257(2):319-330 (1998).
Hartmann, R., et al., Nucleic Acids Res. 26(18):4121-4128 (1998).
Lee, J.W., et al., Mol. Endocrinol. 9(2):243-254 (1995).
Mackay, V., et al., J. Biol. Chem. 251(12):3716-3719 (1976).
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