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HSP90AB1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - HSP90AB1 Antibody (Center) AW5257-U400
    Western blot analysis of lysates from rat L6,Hela,A431 cell line (from left to right), using HSP90AB1 Antibody (Center)(Cat. #AW5257). AW5257 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.
  • IHC-P - HSP90AB1 Antibody (Center) AW5257-U400
    Formalin-fixed and paraffin-embedded human testis tissue reacted with HSP90AB1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - HSP90AB1 Antibody (Center) AW5257-U400
    Flow cytometric analysis of WiDr cells using HSP90AB1 Antibody (Center)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, IHC-P
Primary Accession P08238
Other Accession P34058, P11499, Q4R4T5, Q04619, Q76LV1
Reactivity Human, Rat
Predicted Mouse, Rat, Monkey, Bovine, Chicken
Host Rabbit
Clonality Polyclonal
Calculated MW H=83;M=83;Rat=83 KDa
Additional Information
Gene ID 3326
Antigen Region 438-465 aa
Other Names HSP90AB1; HSP90B; HSPC2; HSPCB; Heat shock protein HSP 90-beta; Heat shock 84 kDa
Dilution WB~~ 1:1000
IHC-P~~1:50~100
FC~~1:10~50
Target/Specificity This HSP90AB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 438-465 amino acids from the Central region of human HSP90AB1.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHSP90AB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HSP90AB1
Synonyms HSP90B, HSPC2, HSPCB
Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.
Cellular Location Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
Citations (0)

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Background

HSPCB are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. This protein normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress.

References

Hoffmann T., Hovemann B.Gene 74:491-501(1988)
Mason A., O'Connor D., Greenhalf W.Submitted (JUN-2000)
Wright L., Barril X., Dymock B.,Chem. Biol. 11:775-785(2004)

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$ 325.00
$ 110.00
Cat# AW5257-U400
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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