|Application ||WB, IHC-P, FC|
|Other Accession||P13638, Q8WMG3, P14231, Q28030|
|Predicted||Rat, Rabbit, Bovine|
|Calculated MW||H=33;M=33;Rat=33 KDa|
|Antigen Region||115-141 aa|
|Other Names||ATP1B2; Sodium/potassium-transporting ATPase subunit beta-2; Sodium/potassium-dependent ATPase subunit beta-2|
|Target/Specificity||This ATP1B2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 115-141 amino acids from the Central region of human ATP1B2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATP1B2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.
Guey,L.T., et.al., Eur. Urol. 57 (2), 283-292 (2010)
Tokhtaeva,E., et.al., Biochemistry 48 (48), 11421-11431 (2009)
Hosgood,H.D. et.al., Respir Med 103 (12), 1866-1870 (2009)
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