|Application ||WB, IHC-P|
|Other Accession||P28492, Q571F8, NP_037399.2|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||H=66;M=66;Rat=66,59 KDa|
|Antigen Region||498-524 aa|
|Other Names||GLS2; GA; Glutaminase liver isoform, mitochondrial; L-glutaminase; L-glutamine amidohydrolase|
|Target/Specificity||This GLS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 498-524 amino acids from the C-terminal region of human GLS2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GLS2 Antibody (C-term E513) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.|
|Tissue Location||Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a mitochondrial phosphate-activated glutaminase that catalyzes the hydrolysis of glutamine to stoichiometric amounts of glutamate and ammonia. This protein is functionally similar to the kidney glutaminase but is a little smaller in size. Originally thought to be liver-specific, this protein has been found in other tissues as well. At least one transcribed pseudogene has been found for this gene. [provided by RefSeq].
Hu, W., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7455-7460(2010)
Suzuki, S., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7461-7466(2010)
Szeliga, M., et al. Glia 57(9):1014-1023(2009)
Tian, C., et al. J. Neurochem. 105(3):994-1005(2008)
Maeshima, H., et al. Prog. Neuropsychopharmacol. Biol. Psychiatry 31(7):1410-1418(2007)
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